Aptamers Selected by Cell-SELEX for Molecular Imaging
نویسندگان
چکیده
منابع مشابه
Generating Aptamers by Cell-SELEX for Applications in Molecular Medicine
Aptamers are single-stranded oligonucleotides of DNA or RNA that bind to target molecules with high affinity and specificity. Typically, aptamers are generated by an iterative selection process, called systematic evolution of ligands by exponential enrichment (SELEX). Recent advancements in SELEX technology have extended aptamer selection from comparatively simple mixtures of purified proteins ...
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objective(s): development of molecules that specifically recognize cancer cells is one of the major areas in cancer research. human epidermal growth factor receptor 2 (her2) is specifically expressed on the surface of breast cancer cells. her2 is associated with an aggressive phenotype and poor prognosis. in this study we aimed to isolate rna aptamers that specifically bind to her2 overexpressi...
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ژورنال
عنوان ژورنال: Journal of Molecular Evolution
سال: 2015
ISSN: 0022-2844,1432-1432
DOI: 10.1007/s00239-015-9716-6